Alli is close to recovering from a knee injury but may not be risked while Toby Alderweireld (leg), Erik Lamela (hip) and Ben Davies (ankle) are all out.
Harry Kane, however, is fit to start after returning early from England duty to work on his sharpness. Christian Eriksen and Danny Rose are also available after shaking off hip and foot problems respectively.
James Collins has overcome the knock which forced him to withdraw from the Wales squad butAndy Carroll is still a couple of weeks away following an ankle injury.
Tottenham squad: Lloris, Vorm, Lopez, Rose, Vertonghen, Carter-Vickers, Wimmer, Walker, Trippier, Dier, Wanyama, Winks, Dembele, Eriksen, Alli, Sissoko, Onomah, Nkoudou, Son, Janssen, Kane.
West Ham squad: Adrian, Randolph, Reid, Collins, Ogbonna, Cresswell, Oxford, Kouyate, Obiang, Fernandes, Nordtveit, Payet, Lanzini, Antonio, Feghouli, Ayew, Sakho, Zaza, Fletcher, Calleri.