United will take on Tottenham at White Hart Lane in the Premier League on Sunday afternoon.
Former Liverpool defender Nicol has backed the Red Devils to pick up all three points from the encounter.
United will head into the match against Spurs on the back of a 2-0 victory over Zorya Luhansk away from home in Europa League Group A.
Jose Mourinho’s side are sixth in the Premier League table at the moment with 21 points from 14 matches.
The Red Devils are nine points behind fourth-placed Manchester City and as many as 13 behind leaders Arsenal. United have won only one of their last eight league matches, drawing six.
The North London outfit won 5-0 against relegation candidates Swansea City at White Hart Lane in the league last weekend.
Meanwhile, Tottenham currently find themselves fifth in the standings with 27 points from 14 matches.
Spurs will head into the game against United on the back of a 3-1 victory over CSKA Moscow at the Wembley Stadium in London in Champions League Group E.